A.  From the Northeast via the New Jersey Turnpike South

Use Exit 4. Bear right out of the toll following signs to Philadelphia and Ben Franklin Bridge. After crossing the bridge take I-676 West, to I-76 East, the Schuylkill Expressway. Follow I-76 East to Exit 346-A (old exit number 40) -- South Street (a left-lane exit). Turn right onto South Street to enter campus. Go to Part E below.

B.  From the West via the Pennsylvania Turnpike

On the PA turnpike, use Exit 326, the Valley Forge Interchange. Take I-76 East for approximately 17 miles until Exit 346A, a left lane exit marked South Street. Turn right onto South Street to enter campus. Go to Part E below.

C.  From the North via I-95 South

Use the I-676/Center City Philadelphia Exit. Follow signs to I-676 West, the Vine Street Expressway. Take I-676 West until I-76 East, the Schuylkill Expressway. Follow I-76 East until Exit 346-A (old exit number 40) -- South Street (a left-lane exit). Turn right onto South Street to enter campus.  Go to Part E below.

D.  From the South via I-95 North

Use the I-676/Center City Philadelphia Exit which is approximately 7 miles north of the airport. Follow I-676 West, the Vine Street Expressway, until I-76 East, the Schuylkill Expressway. Follow I-76 East until Exit 346-A (old exit number 40) -- South Street (a left-lane exit). Turn right onto South Street to enter campus.  Go to Part E below.

E.  From South Street

South Street becomes Spruce Street as you enter the Penn campus.  Houston Hall is located at 3417 Spruce Street (between 34th and 36th Streets), Philadelphia, PA 19104. 

Street parking at the Penn Campus is FREE after 8 PM.  If you prefer to park at a garage or lot, the university recommends the following locations:  38th and Walnut Street (please use 38th Street entrance); 34th and Chestnut Street; Penn Tower Hotel (34th and Civic Center Boulevard); Sheraton Hotel (36th and Chestnut Streets); South Street and Convention Avenue; 32nd and Walnut Street; 40th and Walnut Street.

SEPTA Routes 40, 42, 21 and the trolleys take you to the Penn campus. 
For schedules, see http://www.septa.com.